C1Net Workshop 2 on Metabolic Modelling

Course Timetable and Resources Index

Day

Time

Place

Activity

Links

Lecturer

Monday

13:00

28/09/15

13:30

Mary O'Brien Room

Workshop registration opens.

MP, DF, (KA and NM)

14:00

"

Opening and introductions

DF

14:30

"

L1. Structure of metabolic networks and their representation

slides

MP

15:30

"

Tea/coffee

16:00

"

L2. Basic Concepts for Modelling Enzyme Kinetics

Basic Concepts for Modelling Enzyme Kinetics

DF

17:00

"

P1. Plotting enzyme kinetic functions; graphical solution to a two enzyme system; rough time course calculation for an enzyme-catalysed reaction Plus: Computers: checking internet connectivity, software installati on.

Practical_1 and Installation of ScrumPy

DF, MP, KA

18:30

Lodge

Room registration for Pipe Partridge block (available from 14:00)

19:00

Old Library

Opening reception

19:30

Deneke Dining Hall

Dinner

Tuesday

08:00

Deneke Dining Hall

Breakfast

29/09/15

09:00

Mary O'Brien Room

L3. Further enzyme kinetics for model building, plus

Lecture 3 slides

DF

10:00

L3a. Fitting enzyme kinetica

Lecture 3a slides Supplementary Information on fitting kinetics

DF

10:30

Coffee/Tea

11:00

L4. Python and ScrumPy

Introduction to/Recap of Python

MP

12:30

Mary O'Brien Room

Lunch (buffet)

13:30

Mary O'Brien Room

P2. Python and ScrumPy / L4a: Construction and Analysis of Kinetic Models with ScrumPy (Those remembering their Python and ScrumPy can move ahead to P3)

Construction and Analysis of Models With ScrumPy Practical 2 Instructions

MP, DF, (HH , KA,NM)

14:30

P3. Investigating properties of basic model structures

Kinetic Modelling

MP, DF, (HH, KA, NM)

15:30

Tea/Coffee

16:00

L5. Understanding the control of metabolism - intro to Metabolic Control Analysis

Lecture 5 slides

DF

17:00

P3 continued

MP, DF, (HH, KA, NM)

17:30

Close

19:00

Deneke Dining Hall

Dinner

Wednesday

08:00

Deneke Dining Hall

Breakfast

30/09/15

09:00

Mary O'Brien Room

L6. Applications of Metabolic Control Analysis

DF

10:00

"

P3 conclude and P4. Feedback inhibition.

MP, DF, (HH, NM)

10:30

Coffee/Tea

11:00

P4 continued.

MP, DF, (HH, NM)

12:30

Mary O'Brien Room

Lunch

13:00

Free time. Possibility of punting using the college punts on the river Cherwell, or if unavailable, from the Cherwell Boathouse.

16:00

Mary O'Brien Room

Tea/Coffee.

16:30

L7. Examples of metabolic models: Calvin cycle, threonine synthesis, Entner Duodorff pathway

MP + DF

17:30

S1: Review of outcomes from practicals 3 and 4.

DF, NM

19:00

Deneke Dining Hall

Dinner

Thursday

08:00

Deneke Dining Hall

Breakfast

0

1/10/15

09:00

Mary O'Brien Room

L8. MCA perspective on metabolic engineering from case studies.

DF

10:00

P5. Calvin cycle simulation.

DF, MP, KA, NM

10:30

Coffee/Tea

11:00

P5 cont

DF, MP, KA, NM

12:30

Mary O'Brien Room

Lunch

13:30

Mary O'Brien Room

P6. Engineering threonine production.

DF, KA, NM

14:30

P6 cont

MP, DF

15:30

Tea/Coffee

16:00

G1: Intro to group work problems.

DF, KA, NM

17:30

Close

18:30

Monson Room

Pre-dinner drinks

19:00

Monson Room

Workshop dinner

Friday

08:00

Deneke Dining Hall

Breakfast and room checkout (Lodge)

2/10/15

09:00

Mary O'Brien Room

G1 continued

MP, DF, HH, KA, NM

10:30

Coffee/Tea

11:15

Reports from groups

12:00

Any questions? Closing remark. Presentation of certificates

MP, DF, HH, KA, NM

12:30

Mary O'Brien Room

Sandwich lunch (packed)

13:30

Departure