Delhi Workshop on Metabolic Modelling 2013

This is an activity of the collaborative project Development of Metabolic Models to Support Systems Biology Approaches to Bioenergy Research

About the Workshop

This second workshop will cover kinetic modelling of metabolism and Metabolic Control Analysis, with an emphasis on their application to biotechnology and metabolic engineering.

Timetable

Student Contributions

The last hour of the first four morning sessions will be given over to student presentations. Students will be informed later as to the exact timetabling of their talks.

Typical daily timetable

Mornings, 9:30 -12:30 (MOnday 10:00 - 12:30); Lunch 12:1300 - 14:00; Afternoons, 14:00 - 17:00 (at the latest)

Time	Activity	Who
Mon 15th, AM	Session 1: Revision of mathematical representation of metabolic networks. Enzyme kinetics for modelling	David Fell; Mark Poolman
Mon 15th, PM	Practical 1: Plotting enzyme kinetic functions; graphical soluton to a two enzyme system; rough time course calculation for an enzyme-catalysed reaction	David Fell; Mark Poolman
Tue 16th, AM	Session 2: Building kinetic models of metabolism (? Model optimisation?)	David Fell; Mark Poolman
Tue 16th, PM	Practical 2: Brief Python introduction; kinetic modelling with `ScrumPy`	David Fell; Mark Poolman
Wed 17th, AM	Session 3: Metabolic control analysis - understanding the control of metabolic fluxes and metabolite concentrations	David Fell; Mark Poolman
Wed 17th, PM	Practical 3: Kinetic modelling with `ScrumPy` continued, plus calculation of control coefficients	David Fell; Mark Poolman
Thu 18th, AM	Session 4: Implications of metabolic control analysis for feedback inhibtion and enzyme over-expression. Case studies in biotechnology and metabolic engineering.	David Fell; Mark Poolman
Thu 18th, PM	Practical 4: Simulation of pathway optimisation	David Fell; Mark Poolman
Fri 19th, AM	Session 5: Review and Conclusion: choosing the appropriate metabolic modelling methodology for the problem.	David Fell; Mark Poolman