1 Basics of Modelling Enzyme Reactions

1 Understanding Euler Integration

  1. Open the spreadsheet file Euler.ods (on Linux/the ScrumPy Virtual Machine) or Euler.xls (with Excel). Check that you understand how the column od substrate concentraton values is calculated.

  2. Using the tabs to select the sheets for t=0.01 and t=1.0, look at how the solutions change with increase of the Km, or decrease of the Vm.
  3. Can you add a column that computes the product concentration at each time point?

2 Plotting enzyme kinetic functions

  1. Open gnuplot. (In Linux/the virtual machine, open a terminal window and type `gnuplot'.