|
Size: 2476
Comment: Changed news to MPA 2013
|
Size: 3122
Comment:
|
| Deletions are marked like this. | Additions are marked like this. |
| Line 5: | Line 5: |
| '''Metabolic Pathway Analysis 2013''' was held in Oxford, 16-20 September. See its [[http://www.accliphot.eu/mpa-2013/|website]] for details. ----- '''Latest paper:''' Maurice Cheung et al, A method for accounting for maintenance costs in flux balance analysis improves the prediction of plant cell metabolic phenotypes under stress conditions. The Plant Journal 75, 1050-1061 (2013) [[http://onlinelibrary.wiley.com/doi/10.1111/tpj.12252/abstract|online]] |
|
| Line 6: | Line 9: |
| Metabolic Pathway Analysis 2013 will be held in Oxford, 16-20 September. See its [[http://www.accliphot.eu/mpa-2013/|website]] for details. |
'''Previous paper: '''Mark G. Poolman, Sudip Kundu, Rahul Shaw and David A Fell. Responses to Light Intensity in a Genome–Scale Model of Rice Metabolism. ''Plant Physiology'', 162, 1060-1072, 2013, [[./Publications/articles|PDF]] available. [ [[http://dx.doi.org/10.1104/pp.113.216762|DOI: 10.1104/pp.113.216762]] ] |
| Line 23: | Line 25: |
| Line 25: | Line 28: |
| Line 29: | Line 33: |
Meeting news
Metabolic Pathway Analysis 2013 was held in Oxford, 16-20 September. See its website for details.
Latest paper: Maurice Cheung et al, A method for accounting for maintenance costs in flux balance analysis improves the prediction of plant cell metabolic phenotypes under stress conditions. The Plant Journal 75, 1050-1061 (2013) online
Previous paper: Mark G. Poolman, Sudip Kundu, Rahul Shaw and David A Fell. Responses to Light Intensity in a Genome–Scale Model of Rice Metabolism. Plant Physiology, 162, 1060-1072, 2013, PDF available. [ DOI: 10.1104/pp.113.216762 ]
Background
Our group began nearly thirty years ago with initial interests in computer simulation of metabolism and the theoretical analysis of metabolic control and regulation. Whilst these still remain areas of interest, we have since developed interests in modelling signal transduction, in various different approaches to network analysis of metabolism, and in reconstructing metabolic networks from genomic data. In the course of this research, we have addressed problems in microbial, plant and mammalian metabolism, often in conjunction with collaborators who have contributed experimental results.
Our current work centres on modelling the networks of reactions in cells, with particular emphasis on metabolism. It forms part of the emerging field of Systems Biology, in that we are concerned with understanding how biological function arises from the interactions between many components, and with building predictive models. We have to develop and apply suitable theoretical tools, including metabolic control analysis, computer simulation and other forms of algebraic and numerical analysis. In addition, we are investigating how to decipher the metabolic information contained in genome sequences. We are involved in projects on microbial, plant and animal metabolism, each in collaboration with an experimental team.
Potential applications of our work include the design of changes in cellular metabolism to improve the output of product such as antibiotics, detecting vulnerable sites in cellular networks that could be targets for drugs to control disease-causing organisms, and improved understanding of how organisms manage to adjust their metabolism in response to environmental changes and other signals.
Related Sites
We also host the following web sites related to our research: