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=== Dr Christine Faulkner (Oxford Brookes University) === '''The regulation of cell-to-cell communication during pathogen invasion''' Cell-to-cell communication is a fundamental biological process, necessary for co-ordination of development and environmental responses in multicellular organisms. The receptor-like protein AtLYM2 is located at plasmodesmata and mediates chitin-triggered changes to cell-to-cell communication during fungal pathogen invasion . AtLYM2 functions independently of the chitin receptor CERK1 and thus identifies that there are multiple chitin perception mechanisms in plants. === Dr Santanu Datta === '''Delineating the genetic and chemical vulnerability of anti-infective drug targets''' The equity of a drug target is majorly evaluated by its genetic vulnerability with tools ranging from antisense and microRNA driven knockdowns to induced expression of the target protein. In order to upgrade the process of antibacterial target identification and discern its most effective type of inhibition, an in silico tool box that evaluates its genetic and chemical vulnerability leading either to stasis or cidal outcome was constructed and validated. |
||||||||<height="36px" style="text-align:center; ">'''India-UK Systems Biology of Metabolism, Stress and Disease''' || ||<height="35px">'''<<BR>> ''' ||||||<style="text-align:center;">Seminar Hall, Tower 1, Technology Campus, Salt Lake, University of Calcutta || ||<height="22px">'''Monday''' ||'''21 January 2013''' ||<<BR>> ||<<BR>> || ||<height="22px"><<BR>> ||09:30 – 10:30 ||Registration ||<<BR>> || ||<height="22px"><<BR>> ||'''Introduction''' ||<<BR>> ||<<BR>> || ||<height="40px"><<BR>> ||10:30 – 11:00 ||Welcome ||Prof. D.J. Chattopadhyay (Pro-Vice Chancellor – Acacdemic, University of Calcutta; Prof David Fell, Dr Sudip Kundu || ||<height="41px"><<BR>> ||11:00 – 11:50 ||Prof Arun Lahiri Majumdar and Dr Sonali Sengupta (Bose Institute) ||Plant Systems' Biology: A Bird's Eye View || ||<height="24px"><<BR>> ||'''Session 1''' ||'''Rice Systems Biology''' ||Chair: D Fell || ||<height="24px"><<BR>> ||11:50 – 12:40 ||Dr Mark Poolman (Oxford Brookes University) ||Genome-Scale Metabolic Modelling and its Application to Rice || ||<height="24px"><<BR>> ||12:40 – 14:00 ||Lunch (for all) ||<<BR>> || ||<height="47px"><<BR>> ||14:00 – 14:50 ||Dr Ashwani Pareekh (JNU, New Delhi) ||Dissecting Out The Complex Trait Of Abiotic Stress Tolerance In Plants: Will A Systems Biology Approach Be Of Some Help? || ||<height="24px"><<BR>> ||14:50 – 15:40 ||Dr Sudip Kindu (University of Calcutta) ||Analysis Of Metabolic Interactions Between Cellular Compartments In Rice || ||<height="22px"><<BR>> ||15:40 – 16:00 ||Tea (for all) ||<<BR>> || ||<height="22px"><<BR>> ||'''Session 2''' ||'''Plant Stress and Disease''' ||Chair: to be announced || ||<height="47px"><<BR>> ||16:00 – 16:50 ||Dr Hemant Ritturaj Kushwaha (ICGEB, New Delhi) ||Pathway analysis in view of whole genome studies || ||<height="47px"><<BR>> ||16:50 – 17:40 ||Dr Christine Faulkner (Oxford Brookes University) ||The Regulation Of Cell-To-Cell Communication During Pathogen Invasion || ||<height="24px"><<BR>> ||17:40 – 18:00 ||'''General discussion''' || || ||<height="22px"><<BR>> ||<<BR>> ||<<BR>> ||<<BR>> || ||<height="24px"><<BR>> ||19:30 ||'''Pre-dinner drinks / Dinner (by invitation)''' || || ||<height="24px"><<BR>> ||<<BR>> ||<<BR>> ||<<BR>> || ||<height="22px">'''Tuesday''' ||'''22 January 2013''' ||<<BR>> ||<<BR>> || ||<height="22px">'''<<BR>> ''' ||'''Session 3''' ||'''Plant Metabolism''' ||Chair: M Poolman || ||<height="39px"><<BR>> ||09:00 – 09:50 ||Dr Nick Kruger (University of Oxford) ||Probing the performance of central carbon metabolism in plant cells by ^13^C-metabolic flux analysis || ||<height="41px"><<BR>> ||09:50 – 10:40 ||Prof A S Raghavendra (University of Hyderabad) ||Optimisation of Photosynthesis by Multiple Intracellular Compartments in Plant Cells: A Systems Biochemistry Outlook || ||<height="22px"><<BR>> ||10:40 – 11:00 ||Tea / Coffee (for all) ||<<BR>> || ||<height="24px"><<BR>> ||11:00 – 11:50 ||Prof David Fell (Oxford Brookes University) ||Modelling Tomato Fruit Metabolism || ||<height="24px"><<BR>> ||'''Session 4''' ||'''Modelling Metabolism and Disease''' ||Chair: S Kundu || ||<height="22px"><<BR>> ||11:50 – 12:40 ||Dr Anu Raghunathan (NCL, Pune) ||From Cell Lines To Tissue Specific Flux Balance Models: Cancer Cell Growth And Metabolism || ||<height="24px"><<BR>> ||12:40 – 14:00 ||Lunch (for all) ||<<BR>> || ||<height="40px"><<BR>> ||14:00 – 14:50 ||Prof K V Venkatesh (IIT Bombay) ||Multi-scale Structured Kinetic Model for Analyzing Disease States in Metabolic Syndrome || ||<height="39px"><<BR>> ||14:50 – 15:40 ||Dr Santanu Datta (Cellworks, Bangalore) ||Delineating The Genetic And Chemical Vulnerability Of Anti-Infective Drug Targets || ||<height="24px"><<BR>> ||15:40 – 16:00 ||'''General Discussion and close''' || || |
Meeting Programme
India-UK Systems Biology of Metabolism, Stress and Disease |
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Seminar Hall, Tower 1, Technology Campus, Salt Lake, University of Calcutta |
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Monday |
21 January 2013 |
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09:30 – 10:30 |
Registration |
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|
Introduction |
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|
|
10:30 – 11:00 |
Welcome |
Prof. D.J. Chattopadhyay (Pro-Vice Chancellor – Acacdemic, University of Calcutta; Prof David Fell, Dr Sudip Kundu |
|
11:00 – 11:50 |
Prof Arun Lahiri Majumdar and Dr Sonali Sengupta (Bose Institute) |
Plant Systems' Biology: A Bird's Eye View |
|
Session 1 |
Rice Systems Biology |
Chair: D Fell |
|
11:50 – 12:40 |
Dr Mark Poolman (Oxford Brookes University) |
Genome-Scale Metabolic Modelling and its Application to Rice |
|
12:40 – 14:00 |
Lunch (for all) |
|
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14:00 – 14:50 |
Dr Ashwani Pareekh (JNU, New Delhi) |
Dissecting Out The Complex Trait Of Abiotic Stress Tolerance In Plants: Will A Systems Biology Approach Be Of Some Help? |
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14:50 – 15:40 |
Dr Sudip Kindu (University of Calcutta) |
Analysis Of Metabolic Interactions Between Cellular Compartments In Rice |
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15:40 – 16:00 |
Tea (for all) |
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Session 2 |
Plant Stress and Disease |
Chair: to be announced |
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16:00 – 16:50 |
Dr Hemant Ritturaj Kushwaha (ICGEB, New Delhi) |
Pathway analysis in view of whole genome studies |
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16:50 – 17:40 |
Dr Christine Faulkner (Oxford Brookes University) |
The Regulation Of Cell-To-Cell Communication During Pathogen Invasion |
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17:40 – 18:00 |
General discussion |
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19:30 |
Pre-dinner drinks / Dinner (by invitation) |
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Tuesday |
22 January 2013 |
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Session 3 |
Plant Metabolism |
Chair: M Poolman |
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09:00 – 09:50 |
Dr Nick Kruger (University of Oxford) |
Probing the performance of central carbon metabolism in plant cells by 13C-metabolic flux analysis |
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09:50 – 10:40 |
Prof A S Raghavendra (University of Hyderabad) |
Optimisation of Photosynthesis by Multiple Intracellular Compartments in Plant Cells: A Systems Biochemistry Outlook |
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10:40 – 11:00 |
Tea / Coffee (for all) |
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11:00 – 11:50 |
Prof David Fell (Oxford Brookes University) |
Modelling Tomato Fruit Metabolism |
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Session 4 |
Modelling Metabolism and Disease |
Chair: S Kundu |
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11:50 – 12:40 |
Dr Anu Raghunathan (NCL, Pune) |
From Cell Lines To Tissue Specific Flux Balance Models: Cancer Cell Growth And Metabolism |
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12:40 – 14:00 |
Lunch (for all) |
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14:00 – 14:50 |
Prof K V Venkatesh (IIT Bombay) |
Multi-scale Structured Kinetic Model for Analyzing Disease States in Metabolic Syndrome |
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14:50 – 15:40 |
Dr Santanu Datta (Cellworks, Bangalore) |
Delineating The Genetic And Chemical Vulnerability Of Anti-Infective Drug Targets |
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15:40 – 16:00 |
General Discussion and close |
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